... the 240 mg/m2 dose, the peak rhEndostatin serum level was 11 ug/mL and the mean area under the curve(AUC) was approximately 700 ug*min/ml. This was similar to the AUC for a 50 mg/kg dose in mice, which was shown to be efficacious in tumor...
http://www.usrf.org/breakingnews/endostatin_abs258.html